This research laboratory focuses on the development of label-free and labeled optical microscopy technologies. On one line of activities, digital holography principle is applied for microscopic samples to achieve quantitative phase imaging and optical diffraction tomography. These techniques provide quantifiable and biologically relevant imaging contrast (phase retardation or refractive index) without any fluorescent marker. The tomographic imaging approach serves optical super-resolution in-plane on top of the axial sectioning capability. Alternative schemes of simplified quantitative phase imaging systems are developed for specific applications. On the other line, fluorescence microcopy super-resolution imaging technologies are explored for multi modal microscopic imaging applications.